These changes don’t appear to be inherited - meaning that they likely occur during your lifetime.

CMMLĬMML is linked to genetic changes in myeloid stem cells that cause too many monocytes to be produced. But we do have insight into some of the genetic factors involved in the development of these cancers. The exact causes of both CMML and CML are unknown. Symptoms become much more severe and can be life threatening. Blasts make up 20 percent or more of cells in this phase. New mutations may also happen, making some treatments less effective. This phase indicates 10 to 19 percent of cells are blasts. This phase indicates less than 10 percent of cells are blasts, and you may not have symptoms. The WBCs impacted are called granulocytes.ĬML has 3 phases based on the number of blasts in the blood and bone marrow as well as the severity of symptoms: This category indicates more than 5 percent blasts in the blood and 10 to 19 percent blasts in the bone marrow.ĬML happens when myeloid stem cells divide uncontrollably, making high numbers of blasts that do not work properly. There category indicates 2 to 4 percent blasts in the blood and 5 to 9 percent blasts in the bone marrow. This category indicates less than 2 percent blasts in the blood and less than 5 percent blasts in the bone marrow. One way to categorize CMML is by using the number of blasts present in the blood and bone marrow:

An increase in WBCs that aren’t fully mature - known as blasts - can also happen. Many of these monocytes are poorly developed and don’t function well. CMMLĬMML is characterized by high levels of WBCs called monocytes. Let’s get into the key differences between CMML and CML in terms of how each can affect these cells. Myeloid stem cells develop into the following types of cells: What’s the difference between CMML and CML?īoth CMML and CML impact myeloid stem cells.

Cal vs cml